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Isolated case reports and small series have described altered thyroid function tests in patients treated with GLP-1RAs, including suppressed TSH or fluctuating free thyroid hormone levels, but these changes were typically transient and not associated with progression to overt thyroid dysfunction [30,32]
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Together these data support a stronger brain dependence of the body-weight-lowering effects of GLP-1MK-801 compared with semaglutide

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