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Speakers also addressed common side effects and risks associated with GLP-1 receptor agonists, emphasizing the importance of individualizing treatment to find the best-tolerated dose of GLP-1, particularly when managing gastrointestinal side effects

Mechanistically, L-tryptophan upregulated the expression of GLP-1related genes (e.g., Gcg and Pcsk1 ) in intestinal L cells, further promoting GLP-1 production ( In contrast, some postbiotics may suppress GLP-1 signaling

These findings provide some reassurance regarding the general cancer safety profile of this drug class in human populations, though the limited duration of most studies must be acknowledged when interpreting these results

The Journal of Pediatrics

Mutagenesis facilitated crystallization of GLP-1R