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Many people notice them from time to time, and for most, they fade with simple adjustments

Although tachyphylaxis to this effect may occur with long-acting GLP-1 receptor agonists, GLP-1-associated slowing of gastric emptying does not appear to be responsible for the nausea and vomiting often reported with the use of GLP-1 receptor agonist treatment

Goodwin, J

The prevailing model held that these drugs act directly on GLP-1 receptors in the brain, while our study provides evidence for an alternative pathway. For this study, the researchers used the weight-loss drug liraglutide, marketed under the brand names Victoza and Saxenda

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It remains unclear whether there is a relationship between the central actions of peripheral GLP-1 and the GLP-1-producing neurons in the brain stem, but it is clear that one of the most important actions of peripheral GLP-1 is to regulate food intake in agreement with its ileal brake function