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Zuyi Yang, orcid.org/0009-0000-3317-4136

The issue may not be immune activation itself, but a failure of neuroimmune resolution

The path through a plateau is not a higher dose or harder discipline, its a more complete picture of what the body is actually doing

The absence of liver toxicity with orforglipron, despite its primary route of elimination through hepatic CYP3A-mediated metabolism, suggests that the hepatotoxicity observed with danuglipron and lotiglipron was related to the specific chemical structures of those molecules rather than to the class of small-molecule GLP-1 agonists as a whole

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