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Studies examining patients on antidepressants who started GLP-1 receptor agonists found that those on bupropion specifically tended to fare better in terms of weight loss compared to those on SSRIs like sertraline or fluoxetine

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The 4.5 mg dose produced 10.8% reduction (11.5 kg average)

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Large-scale randomized controlled trials and post-marketing surveillance data indicate that these medications do not typically cause clinically significant liver injury in most patients

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