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Even in mandate states, reviewers deny requests where the provider's note emphasizes appearance, clothing size, or quality of life rather than medical comorbidities

A 2025 clinical trial published in JAMA Psychiatry studied once-weekly semaglutide specifically in adults with alcohol use disorder

Efficacy and safety of finerenone in patients with an acute change in estimated glomerular filtration rate in the prespecified FIDELITY pool analysis

This happens because fat cells convert a hormone called androstenedione into estrone, a type of estrogen

Some people do better at moderate doses (1 to 1.7 mg) with excellent tolerability than at maximum dose (2.4 mg) with persistent side effects

This problem is known as Raynaud's phenomenon