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GLP-1 (Glucagon-like peptide-1) is a natural hormone that helps regulate appetite and promote weight loss

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Smooths out post-meal sugar spikes, helping maintain steady energy

This striking difference is probably a result of the fact that agonists bind class B GPCRs predominantly at their large extracellular N-termini and TM1 helices, whereas class A GPCRs mainly interact with agonists deep inside the TM helical bundle and/or at the extracellular loops (ECLs) [15]

[15] and under the brand names Wegovy and Kayshild for the treatment of metabolic-associated steatohepatitis (nonalcoholic steatohepatitis) and liver cirrhosis