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HR = 0.90 (125)], even in those patients with previous heart failure (132134), suggesting that the increased risk with saxagliptin is not mechanistically related to the inhibition of DPP-4 per se , but the cause is still unexplained

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doi:10.1038/s41366-025-01859-6 51

Theres no fixed minimum interval, but allowing time for healing, sleep recovery, and re-establishing eating patterns is usually sensible