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Glucagon-like peptide-1 (GLP-1) and glucose dependent insulinotropic polypeptide (GIP) are the two main incretins and are secreted by enteroendocrine L- and K-cells, respectively

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With a molecular weight of 4186 Da, exendin-4 should not either be able to cross the placenta, however, when the pregnant mice had systemic inflammation, exendin-4 did cross the placenta (Garcia-Flores et al

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Understanding your metabolic predispositions, GLP-1 receptor sensitivity, and insulin dynamics can help frame a precision-focused conversation with your provider about which medication aligns with your biological profile and health goals

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He points out that its a common practice for healthy people to take vitamins and supplements that are purported to slow the effects of aging, specifically antioxidants, even though the research demonstrates that they dont significantly impact health and we dont know enough about their effects

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