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Exendin-4 appears to activate the -cell EGFR to promote -cell proliferation 4, 7, 10, 11

This sequence leads to glucose-dependent insulin secretion through sensitization, thus ensuring optimal maintenance of glucose levels

In a 48-week clinical trial, higher doses consistently led to greater average weight loss: Weight loss by dose (48-week clinical trial) In this trial, at the highest dose (12 mg), people lost an average 24% of their starting weight on average

doi: 10.1152/ajplung.00091.2015

To estimate the number of people worldwide with obesity, we also used 2016 population data for adult men and women from each country from the World Bank