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Early in the disease, beta cells compensate by increasing insulin production, preventing hyperglycemia

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Diese drei Mechanismen wirken synergistisch und beeinflussen gemeinsam Appetit, Glukosehaushalt und Energieverbrauch insbesondere im Kontext von Adipositas, Insulinresistenz und Leberverfettung

In mice single-cell RNA sequencing identified a subpopulation of GLP-1R-positive memory T-cells that was mainly composed of exhausted CD8+ T cells: functionally, stimulation of the GLP-1R on these cells was found to mediate apoptosis and anergic signals, thereby suppressing effector T-cell function and the inflammatory response ( 3.2 Intestinal mucosal barrier IELs are a heterogeneous population of T cells located among intestinal epithelial cells (IECs), where they contribute to maintaining mucosal barrier integrity (57)

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