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ApoB, the single best blood marker of how many cholesterol-carrying particles you have, also tends to come down

#Sanofi #RareDisease #AATD Results from a phase 2 study evaluating an investigational treatment for Alpha-1 Antitrypsin Deficiency (#AATD), achieved all primary and key secondary endpoints

Mesolimbic reward areas receive direct innervation from GLP-1-producing neurons, indicating hindbrain-derived GLP-1 may influence reward-related behaviors ( In terms of clinical evidence, randomized clinical trials have shown that the GLP-1 receptor agonist exenatide may reduce alcohol consumption, particularly in individuals with co-occurring alcohol use disorder and obesity (ClinicalTrials.gov) or recently completed ( Given the lack of evidence supporting a potential effect of GLP-1 receptor agonists as treatment in methamphetamine (METH) dependence in either a clinical or preclinical setting, the aim of this study was to investigate whether administration of liraglutide could reduce METH intake in a rat model of intravenous self-administration (IVSA)

The explanation is that GLP-1 likely affects heart rate indirectly, through autonomic nervous system modulation rather than direct cardiac effects

10.1152/ajpendo.1997.273.5.E981

How Meltwater Explore+ helps marketers understand platform-specific audience behavior Use Case 1: Identifying platform-specific audience dynamics The insight GLP-1 audiences behave differently across Reddit, X, and Pinterest, making aggregate social listening insufficient for understanding consumer behavior