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Medullary thyroid carcinoma, the specific cancer type mentioned in the tirzepatide boxed warning, arises from C-cells and accounts for roughly 3-5% of all thyroid cancers
Key variables such as the degree of weight loss, medication adherence, timing and duration of GLP-1RA exposure relative to the BOTOX index event, and behavioral or lifestyle factors were unavailable and may have influenced the observed associations

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