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GLP-3 might fit into combination strategies by providing complementary metabolic effects not fully achieved by GLP-1 alone, potentially enhancing specific aspects like fat oxidation or metabolic flexibility, possibly allowing lower doses of each peptide with fewer side effects, or addressing metabolic resistance that can develop with single-peptide approaches

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Patients with type 2 diabetes already have a two- to threefold higher baseline risk of pancreatitis due to metabolic stress, dyslipidemia, and insulin resistance

muciniphila also raised the release of ECs