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Singapore: Imperial College Press, Print

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Moreover, the regulation of sodium and calcium homeostasis in cardiomyocytes and coronary endothelium is directly translated into improved contractility and relaxation of the heart ( Diuretic and natriuretic effects of SGLT2 inhibitors contribute to the reduction of intravascular volume and decrease in blood pressure, lowering afterload, improving cardiac efficiency, and reducing ventricular mass index (Mazidi et al., 2017

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Central GLP-1R activation in the hypothalamic arcuate nucleus and brainstem nucleus tractus solitarius modulates appetite circuits, reducing food intake through both immediate satiety signaling and longer-term feeding behavior regulation

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