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Glucagon is liberated from pancreatic cells by PC2, wherea GLP-1 and GLP-2 are liberated from the intestinal L cells by PC1/3
While they share similar effects, their key difference lies in the pharmacokinetics, specifically the half-life
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The biology of the human SGLTs has also extensively reviewed elsewhere
Orforglipron is a selective and potent partial agonist that biases the activation of GLP-1 receptors towards the G-protein signaling pathway and exhibits a lesser ability to recruit -arrestin
