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60% of the weight comes back within a year of stopping GLP-1s

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We don't have good data on: *What outcomes look like at various sub-therapeutic doses *Which patients might benefit from lower, more frequent dosing versus higher, less frequent *How hormonal changes (hello, perimenopause) affect optimal dosing *Long-term effects of maintenance microdosing after weight loss goals are met The doctor quoted in the article is right that standard doses exist because they've been proven effective