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The heart rate effect and the cardiovascular protection effect operate through entirely different mechanisms and do not negate each other

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15, 16 GLP-1, endogenously produced in the L-cells of the distal ileum and colon, modulates appetite leading to decreased food intake and thus body weight

As a precaution, people with a personal or family history of medullary thyroid carcinoma (MTC) or MEN2 syndrome should not use GLP-1 RA [enttoday.org, droracle.ai]

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