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As mentioned before, obesity is associated with a state of chronic, low-grade inflammation characterized by abnormal cytokine production and the activation of inflammatory signaling pathways in adipose tissue [76]

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Weight loss by calorie restriction does not alter appetite-regulating gut hormone responses from perfused rat small intestine

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If a patient has to ask themselves, Do I eat or do I fill my prescription? then, more often than not, the patient will not fill their prescription at the pharmacy