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Interestingly, in a retrospective study of 186 patients (56% type 1 diabetes mellitus) from the Netherlands, dyspeptic symptoms, with the exception of early satiety and abdominal pain, were unrelated to delayed gastric emptying [69]
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How May GIP Enhance the Therapeutic Efficacy of GLP-1

One more thing to consider is whether or not oral GLP-1 agonists obtain FDA approval for obesity

Moreover, in dual agonisms, GLP-1 could have a protective role against the hyperglycemic effect of glucagon
At the same time, GLP-/GIP dual agonists may also be an effective treatment option for non-diabetic patients with abnormal lipid metabolism