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Metformin, the current first-line treatment in T2DM, has an unclear antidepressant effect [166] despite identified direct mechanisms and pleiotropic effects, including inhibition of angiotensin II and NF-B factor, normalization of gut microbiota, and intestinal permeabilization, and in vivo experimental data [167] supporting its potential benefits

Probiotics may help with weight loss, but more research is needed

Zepbound's dual-action targets GLP-1 and GIP receptors, curbing appetite and promoting fullness

Also, the NGT relies on expert consensus rather than objective clinical research data, is subject to personal interpretation, may be influenced by factors such as hospital or healthcare system policies, and does not account for long-term outcomes, cost analyses, or adverse effects

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