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Protection and Reversal of Excitotoxic Neuronal Damage by Glucagon-Like Peptide-1 and Exendin-4

Changes in bowel habit that represent a significant departure from an individual's normal pattern, particularly in those over 60 years or with family history of colorectal cancer, should be evaluated in accordance with NICE guideline NG12 on suspected cancer recognition and referral

Adding a glucose-raising signal to a molecule aimed at metabolic health looks, at first glance, like a mistake

1 While the trial was not designed as a weight loss trial, participants in the trial who received semaglutide still lost an average of 9.4% of total body weight which was sustained throughout the trial