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Incretin-based treatments for T2D and obesity result in improved glucose-dependent insulin secretion, appetite suppression, and delayed gastric emptying, thereby leading to improved glycemic control and bodyweight reduction [7]

Impact of glucagon-like peptide-1 receptor agonists on diabetic retinopathy: a meta-analysis of clinical studies emphasising retinal changes as a primary outcome

Diarrhea affects some patients, particularly during dose escalation phases

Pharmacological characterization shows tirzepatide is an imbalanced agonist with full efficacy at GIPR but only partial efficacy at GLP-1R, exhibiting biased signaling that favors cAMP over -arrestin recruitment

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