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Preclinical trials demonstrate that this co-agonist improves glucose tolerance, indicating that the GLP-1 activity can successfully buffer the hyperglycaemic potential of GcgR agonism
However, significant variations in control types (placebo, MET, or intensive lifestyle), concomitant medications, and follow-up windows mean that a robust head-to-head ranking of strategies is still lacking

HR, 1.12

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