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doi: 10.1210/jc.2014-2547 26 HelstedMMGasbjergLSLanngARBergmannNCStensenSHartmannBet al

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Dulaglutide is covalently linked to human immunoglobulin IgG 4 heavy chain molecules to reduce immunogenicity, enhance water solubility, and avoid degradation by DPP-4

These reports also suggest that AGEs stimulate tau hyperphosphorylation in vivo, and the glycation of A influences its aggregation [209,211,212]

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