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Current clinical guidelines from the American College of Obstetricians and Gynecologists and the Endocrine Society advise immediate discontinuation of all AOMs upon pregnancy detection

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Investigations All patients presenting with rectal bleeding should have routine bloods * (FBC, U&Es, LFT, clotting) and a Group and Save requested (as a minimum)

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May delay absorption of oral medications

In humans, intravenous infusion of a somatostatin analog, octreotide, 30 min prior to carbohydrate meal (Hycal) significantly impairs insulin, GLP-1, and GIP secretion in both lean and obese women, yet post-heparin LPL activity (contributions from adipose, skeletal and cardiac tissue) is unchanged 1.5 h post-peak insulin in lean and obese women (Ranganath et al., 1999)