tirzepatide pregnancy human data Glucagon-like peptide-1 receptor agonist use in pregnancy: a review Does Tirzepatide Cause Birth Defects?

Serious but less common side effects include potential issues with the pancreas, such as pancreatitis (inflammation of the pancreas)

Acting on both incretin hormones, GIP and GLP-1, tirzepatide helps the body regulate blood sugar more effectively while promoting more weight loss and offering additional metabolic benefits over previous medications

Each generation adds receptors, weight loss, and metabolic benefits, but also adds complexity and reduces the length of available safety data

Manufacturer-assistance programs provide temporary cost relief to eligible patients

Approved by the US FDA in December 2025 for chronic weight management

The next generation: investigational oral GLP-1s Another watched candidate is orforglipron , an investigational, once-daily oral GLP-1 drug being studied for type 2 diabetes and obesity