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Liver Suppresses hepatic glucose production Enhances lipoprotein uptake Regulates triglyceride and free fatty acid metabolism Hepatic insulin resistance is a key driver of hyperglycemia and fatty liver disease

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Excretion Following oral administration of a 70 mg dose of radiolabeled lisdexamfetamine dimesylate to 6 healthy subjects, approximately 96% of the oral dose radioactivity was recovered in the urine and only 0.3% recovered in the feces over a period of 120 hours