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LY3298176, a novel long-actingGIP/GLP-1 coagonist, shows enhanced activity on weight loss and energy utilization whilst maintaining its efficacy for glycaemic control

doi: 10.1093/ibd/izae250

Importantly, despite the evidence for use of SGLT-2 inhibitors for DKD treatment, they should not be used in patients with type 1 diabetes because of the risk of euglycaemic diabetic ketoacidosis

Zepbound, approved by the FDA, is dedicated to chronic weight management

These hormones exert direct effects on the liver

Evidence suggests that GLP-1s are not only effective in preventing the accumulation of amyloid beta, a protein commonly associated with Alzheimer's, but also in mitigating the hyperphosphorylation and aggregation of tau, another critical protein in the disease's progression