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Description
If you have a history of significant GI issues or poor tolerance to other medications, semaglutide lower discontinuation rate (5-7% vs 12-18%) suggests better overall tolerability
O'Connor et al., 2015
However, high rates of weight loss carry substantial risks of muscle loss
The benefit of SGLT2i therapy beyond improved glycaemic control was first reported in the EMPA-REG study which reported a reduced incidence of major adverse cardiovascular events in patients with type 2 diabetes [19]
Home monitoring tools can help track glucose trends and identify patterns that guide dosing decisions
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