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(New England Journal of Medicine) Why it sits in a different bucket than GLP-1 peptides GLP-1 peptides are generally appetite/satiety signalling first. Tesamorelin is more hormonal axis + fat distribution (VAT) first. (ScienceDirect) For a direct comparison of the leading compounds studied for fat reduction, including GLP-1, dual and triple receptor agonists, see our breakdown of the best peptides for weight loss

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Physical activity levels: Whilst exercise may feel challenging when fatigued, maintaining gentle activity can support energy regulation and metabolic adaptation

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