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In this Review, the authors discuss guideline-directed medical therapy for diabetic kidney disease and the evolving clinical evidence for next-generation therapies, including incretin-based therapies, endothelin receptor antagonists, aldosterone synthase inhibitors, soluble guanylate cyclase agonists and anti-inflammatory therapies.

Patients initiated on GLP-1 receptor agonists should be evaluated every 3-6 months after reaching their maintenance dose, with more frequent monitoring (mont...

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