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Important considerations include: GLP-1 agonists are generally well-tolerated in people with hypertension They do not typically cause dangerous drops in blood pressure Dehydration from gastrointestinal side effects (nausea, vomiting, diarrhoea) can occasionally affect blood pressure and kidney function, so maintaining adequate fluid intake is important If you take diuretics (water tablets), ACE inhibitors or ARBs for blood pressure, your doctor may monitor you more closely during the initial weeks of GLP-1 therapy Seek medical advice promptly if you experience persistent gastrointestinal symptoms that prevent adequate fluid intake NICE guidance (NG28) supports the use of GLP-1 agonists in people with type 2 diabetes who meet specific criteria, with preference for agents with proven cardiovascular benefits in those with established cardiovascular disease

Upon its discovery, GLP-1 immediately sparked great interest among drug developers as it showed tremendous potential to be developed as a novel antidiabetic medication

integration with a primary care provider remains essential for safe, coordinated GLP-1 therapy

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At a high level, the TrumpRx initiative underscores a growing push to bypass pharmacy benefit managers and improve price transparency.