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Role of glucose-dependent insulinotropic polypeptide in adipose tissue inflammation of dipeptidylpeptidase 4-deficient rats
Understanding this dual role has important therapeutic implications, as G protein-biased GLP-1 receptor agonists with reduced -arrestin recruitment show enhanced anti-hyperglycemic efficacy through avoidance of receptor desensitization, while the requirement for -arrestin-2 in ERK/CREB activation at therapeutic concentrations explains why complete elimination of -arrestin-2 recruitment may not be optimal for all applications
This consistency helps establish a routine and reduces the likelihood of missed doses
Disproportionality analysis from World Health Organization data on semaglutide, liraglutide, and suicidality
Its biology fighting a toxic environment
The Lancet Diabetes & Endocrinology , 5 (9), 743752
