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Physiological Reviews , 87(4), 14091439

Especially in an active or aspiring active person

Estrogen decline alters how the body stores fat, increases appetite signaling and reduces resting energy expenditure

It may be prescribed alone or with other diabetes medications such as metformin, sulfonylureas, or insulin

By contrast, insulin stimulates leptin secretion from adipose tissue

The magnitude of weight loss varies by product: semaglutide 2.4mg (Wegovy) can achieve approximately 15% reduction in body weight, while liraglutide 3mg (Saxenda) typically produces around 8% weight loss
