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Jul 2016;20(14):2955-73

In neurons, it involves the activation of PI3K/Akt signaling pathway, inhibition of GSK-3, reducing tau phosphorylation, promotion of mitochondrial biogenesis, activation of the Bcl-2 family proteins, and inhibiting apoptosis

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[40] In another study, proanthocyanidins upregulated liver concentrations of nicotinamide adenine dinucleotide (NAD+), [41] which profoundly benefits mitochondrial health and upregulates a pro-metabolic gene called sirtuin 1

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