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What many patients experience instead is a weight-loss plateau, which happens when the body adjusts to a lower weight and metabolism slows slightly

The general mean weight reduction for TZP and placebo from weeks 0 to 88 were respectively 25.3% and 9.9% ( 2.3 Tirzepatide and hypertension: the role of insulin resistance and hyperinsulinemia Clinical studies showed that concomitant developments in insulin sensitivity, -cell, and -cell function underpin the effects of TZP on GC

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Holst JJ, Gasbjerg LS, Rosenkilde MM

But it does not force you to make better food choices, exercise, sleep adequately, or manage stress

Protein triggers your own satiety hormones (like GLP-1) and, most crucially, [helps] maintain precious muscle mass that keeps your metabolism from crashing, says John La Puma, MD, FACP , a board-certified internist and author of ChefMD's Big Book of Culinary Medicine