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At the starting dose, injection volume is small, which minimizes injection site reactions

However, we still dont know the long-term safety and risks of the drug as research is ongoing

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It tells the pancreas to produce insulin, slows gastric emptying, and signals to the brain that food has arrived

That is higher than semaglutides discontinuation rate in STEP 1, which was around 7%

The Evaluate Renal Function With Semaglutide Once Weekly (FLOW) trial is the first dedicated kidney outcome study specifically designed to assess the effect of a GLP-1 receptor agonist (once-weekly subcutaneous semaglutide) in people with type 2 diabetes mellitus and CKD at high-risk of progression (Table 1, Fig