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Weight loss was minimal (perhaps due to reduced penetration to brain or lower potency some trials showed weight neutrality with albiglutide) ( [6] )

The glucagon receptor component is expected to provide unique metabolic effects including increased energy expenditure and enhanced hepatic lipid oxidation, which may contribute to the substantial body weight reductions observed in Phase 2 clinical trials

However, our confidence in selecting medications to improve outcomes has improved, in part because of regulatory requirements to include older people in trials to determine the efficacy and safety of new drugs for diabetes [264, 265]

HbA1c evaluations conducted every 3 to 6 months are critical for assessing glycemic control, with anticipated decreases of 0.5% to 1.5%

doi: 10.1056/NEJMoa1901118 44 GersteinHCSattarNRosenstockJRamasundarahettigeCPratleyRLopesRDet al

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