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Domperidone shows effectiveness as a selective dopamine D2 antagonist that does not cross the bloodbrain barrier [65]

Thirteen studies were performed in the United States [11, 1517, 20, 22, 35, 36, 40, 4346], 9 in Denmark [12, 13, 18, 19, 21, 24, 28, 31, 34], 4 both in China [23, 33, 48, 49] and Slovenia [2527, 39], 3 in Canada [14, 29, 47], 2 in Italy [37, 38], 1 in United Kingdom [30], Sweden [32], Australia [41], and Netherlands [42], respectively

Review distribution breakdown The rating distribution shows a classic bimodal pattern, heavy at the top and heavy at the bottom with relatively less in the middle

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This difference may influence a patients preference or compliance with their treatment regimen