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It works through AMP-activated protein kinase (AMPK) activation, which actually shares some mechanistic overlap with ketosis

How Ozempic affects your digestive system The very mechanism that makes Ozempic effective controlling blood sugar and promoting weight loss can also cause digestive issues, including constipation and diarrhea

2023bSemaglutide in HFpEF across obesity class and by body weight reduction: a prespecified analysis of the STEP-HFpEF trial

Myint, M

Last reviewed: May 20, 2026 Last updated: May 20, 2026 Written by: Jay Hastings, CEO of PlexusDx Jay Hastings is the CEO of PlexusDx, a precision health company focused on genetic testing, blood biomarker insights, and personalized wellness recommendations