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Beyond appetite suppression, semaglutide improves insulin sensitivity and shifts metabolism toward fat utilization over carbohydrate dependence

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R.ChengI.et al (2020)

Notably, AGEs exposure significantly reduces sperm motility, particularly progressive motility ( 4 Damage to the environment surrounding spermatogenesis 4.1 Sertoli cell The number of SC in the adult testis determines daily sperm production, as each SC can maintain a limited number of germ cells ( in vivo and in vitro studies have demonstrated that high glucose levels upregulate Apelin (APLN) in SC, which subsequently downregulates cell junctionrelated genes such as connexin 43 (Cx43) and zonula occludens-1 (ZO-1), ultimately compromising the integrity of the BTB ( 4.2 Increased permeability of blood-testis barrier The bloodtestis barrier (BTB), also referred to as the SC barrier, is a critical structural and functional component of the seminiferous tubules