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Glucose, insulin, and PTTs Male C57BL/6J, Glp1r KO, and db/db mice were fasted overnight (18:00 to next 10:00) or for 4 h (9:0013:00) in GTT, for 4 h in ITT, and overnight in PTT

Mice were euthanized 12 h after treatment by CO 2 inhalation, and major organs were collected

Individuals with specific risk factors, such as a history of pancreatitis or certain medical conditions, should discuss their options with a healthcare provider

However, patients with prior pancreatitis appear at elevated risk for recurrence when taking these medications

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Most studies have been short-term (812 weeks), involved small sample sizes, and used heterogeneous probiotic formulations, making it difficult to draw definitive conclusions about efficacy or to identify which specific strains might be beneficial