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Daily dosing compensates by providing frequent small amounts that accumulate to therapeutic levels over time
Furthermore, GLP-1Rs on IELs have been found to regulate the metabolic effects of GLP-1 in animal models by entrapping it, thereby reducing its systemic availability and lowering its plasma concentrations (62)

doi: 10.2337/dc19-0749, PMID: [DOI] [PubMed] [Google Scholar] 57
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However, treatment with liraglutide was associated with a significant increase in serious cardiac side-effects (12 versus three
10.1136/bmj.l4898 38 SunF.WuS.GuoS.YuK.YangZ.LiL.et al (2015)
