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Accumulation of methylglyoxal (MG) contributes to glucotoxicity and mediates beta cell apoptosis

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The Danish drugmaker released late-stage data showing that the upcoming injection CagriSema failed to match the weight loss of Eli Lillys Zepbound.

Insulin resistance and chronic hyperglycemia cause a cascade of pathological events in the brain, including neuroinflammation, impaired neurotransmitter systems and energy metabolism, oxidative stress, and vascular pathologies that ultimately lead to neurodegeneration, loss of synaptic plasticity, brain aging, cognitive impairment, and dementia

Moreover, in collaboration with the CNRS (National Center for Scientific Research), we have developed a specific analytical method based on stable isotope measurement