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New England Journal of Medicine (2025) 6

TashiroHTakahashiKUchidaMKuriharaYSadamatsuHTakamoriAet alEffect of azithromycin on exacerbations in asthma patients with obesity: protocol for a multi-center, prospective, single-arm intervention study

Psychological support addresses the behavioural and emotional aspects of weight management

Trials including SUMO-1 and SUMO-2 showed dose-dependent weight loss, with 15-mg doses producing approximately 20-21% body weight reduction over 72 weeks compared to 10-15% at lower doses

A greater proportion of patients who received midazolam nasal spray were seizure-free 6 h after active treatment compared with placebo (55% vs 39%, respectively

Vegetable consumption also increases natural GLP-1 secretion during digestion, via the production of short-chain fatty acids