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NICE guidance (NG88) on heavy menstrual bleeding recommends investigation for women with persistent changes in bleeding pattern, particularly those over 45 years or with risk factors for endometrial pathology

doi: 10.1172/jci.insight.140532 87 StefanNSippelKHeniMFritscheAWagnerRJakobCEMet al

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Similarly, elevated IL-1 levels have been observed in elderly patients with mild cognitive impairment compared with healthy controls [10]
Qian SW, Tang Y, Li X, Liu Y, Zhang YY, Huang HY, Xue RD, Yu HY, Guo L, Gao HD, Liu Y, Sun X, Li YM, Jia WP, Tang QQ
