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Some researchers have even reported cases of severe thiamine (vitamin B1) deficiency leading to Wernicke encephalopathy, a potentially dangerous neurological condition

Generally, yeshigher doses (1.0 mg to 2.4 mg weekly) produce faster weight loss than lower doses because appetite suppression is more pronounced

* Correspondence: Nemanja Dimic, [email protected] Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

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The hormone also suppresses glucagon, preventing the liver from releasing additional glucose into the bloodstream
Yet, as O'Donnell notes, on-again-off-again use is already in the cultural zeitgeist
