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Arnaud L, Benech P, Greetham L, Stephan D, Jimenez A, Jullien N, et al

These symptoms are often manageable, particularly when the dose is increased gradually and patients are given practical guidance on meals, hydration, and portion sizes

Epidemiology of Heart Failure

Phase 3 trials (the TRIUMPH programme, registered on ClinicalTrials.gov) are currently underway, evaluating retatrutide across broader populations including those with cardiovascular disease, type 2 diabetes, and obesity-related complications

for semaglutide, a 2-month washout period is recommended before conception) [1] Certain eating disorder subtypes, particularly those with purging behaviours or severe restriction Any decision to prescribe GLP-1 agonists should involve multidisciplinary input , ideally including endocrinology or weight management specialists, mental health professionals with eating disorder expertise, and the patient's GP

Their influence on human fertility appears largely indirect , mediated by correction of metabolic disturbances that impair reproductive physiology