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This article examines clinical safety data, GI mechanisms, and how genetic predispositions may influence medication tolerance in IBD patients see

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Exposures Two cohorts were assembled, with the first composed of patients who started and continued on GLP-1 receptor agonists or DPP-4 inhibitors between 1 January 2007 and 31 December 2020 and the second composed of patients who started and continued on GLP-1 receptor agonists or SGLT-2 inhibitors between 1 January 1 2013 and 31 December 2020

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Preclinical and observational data suggested possible benefits, spurring rigorous clinical testing